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" ... The cynic in me says that if this were truly a patient education website, you'd go to a page where you'd learn of all three FDA-approved prescription drugs to treat OIC. There, you'd learn that the FDA has also approved methylnaltrexone subcutaneous injection (Relistor; Salix), another opioid antagonist, and lubiprostone (Amitiza; Sucampo/Takeda), an oral chloride channel activator. You might also learn that alvimopan (Entereg; Merck, acquired by Cubist buyout) is another oral PAMORA that's used only for the short term in hospitals but isn't expressly approved for OIC. ... "