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" ... “Our interest in this combination arose because both drugs individually have been shown to have anti-tumor effects in pancreatic cancer,” read a statement from two of the authors of the paper: Chi Dang, director of the Ludwig Institute for Cancer Research and Anirban Maitra, scientific director of the Center for Pancreatic Cancer Research at MD Anderson Cancer Center. “To our utter surprise, both HCQ and CQ when combined with metformin resulted in a surprising death rate in 30-40% of mice. In contrast, there were no deaths in the single treatment groups,” said the authors. ... "