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" ... First, why do targeted therapies fail? The researchers claim that, during the experiment, nearly every patient developed multiple forms of drug resistance. They’re confident that this could explain why targeted therapies often fail and change how clinicians treat metastatic cancers. ... "
" ... O’Day hopes to have her first product in 15 to 18 months, biomarkers for one particular drug for metastatic cancer. In February, Olaris received a grant from the Michael J. Fox Foundation for Parkinson’s Research to work to identify biomarkers that can detect Parkinson’s at its earliest onset, seen as a critical step to improving patient outcomes for the disease. ... "
" ... The recent approval is based on results from clinical trials. In the Phase III trial, dubbed POLO, the drug was given to 154 patients with gBRCAm metastatic pancreatic cancer whose disease had not progressed on 1st-line platinum-based chemotherapy. Patients who received Lynparza lived nearly twice as long without their disease worsening than those who received the placebo. For example, those who received Lynparza went an average of 7.4 months before their disease began to worsen. ... "
" ... “As a frontline physician who cares for Covid-19 patients, as well as patients with metastatic cancer, elderly, diabetics, asthmatics, and other patients at risk for severe illness from Covid-19, I’ve seen how important it is to do everything we can to mitigate risk for vulnerable patients,” she said. “Vaccination is a key part of protecting these populations.” ... "
" ... “We’re working to develop a combination clinical trial of anti-CTLA-4 and anti- TGF-β for metastatic prostate cancer. This mechanism may be at play in other tumor microenvironments and needs to be studied further,” said Sharma. ... "