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" ... The production of melanin is in the lower levels of the skin, and the pigmentation process resembles that of an assembly line. Hyperpigmentation is the excess production of melanin by the melanocyte cells of our body. Specific triggers send signals to melanin sites which activate the enzyme tyrosinase. The stimulated tyrosinase encourages melanocytes to produce excess melanin creating darker pigment. The over production of melanin disperses upward in clumps that show as dark spots on the surface of the skin. The sooner you prevent and correct for hyperpigmentation on the skin, the better the results. As skin ages, your body's melanin distribution becomes more spread out, and darker spots begin to appear on your skin. To effectively treat hyperpigmentation a comprehensive approach that includes both in-office and at home skin care regimen is necessary to control and fade it. ... "
" ... “We think that in a partially spotted zebra like Tira, the melanocytes are still uniformly and ubiquitously distributed, however the melanocytes don’t know where they are on the body”, Professor Barsh elaborated. “In other words, partial spotting in zebras is not an abnormality of melanin synthesis but instead is an abnormality of melanocyte identity.” ... "