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" ... Botstein’s comments contrast sharply with those I heard from Andy Grove, in a conversation we had several years ago. Grove, at the time, seemed frustrated, maddened even, by what he perceived as biologists' need to completely understand something before they were willing to experiment with a potential solution. He suggested medicine could profoundly benefit from more of an engineering mindset, where you have a draft of a solution, try out it, see what happens, and iteratively improve it until you get it right. ... "