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" ... Jain found that this group of six patients (median age 60; age range 37-62) all had atypical changes in their macula, the central part of the retina that allows us to have clear central vision. The patients described difficulty reading in dim light and diminished central visual acuity. The patients underwent genetic testing to determine if there was any basis for hereditary retinal loss, with none demonstrating any such evidence of a link. Other than Elmiron, there was no clear etiology based on other findings in their medical history that explained the concerning retinal changes found in all six patients. This led the researchers to issue a warning in 2018 that long-term use of Elmiron could potentially lead to retinal damage. ... "
" ... The macula is a 6mm (1/4 inch) wide yellow spot at the centre of the retina responsible for high-resolution vision. ... "