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" ... Naloxegol (Movantik) is the first oral mu-opioid receptor antagonist to be approved for treatment of opioid-induced constipation. It may be more effective than lubiprostone (Amitiza) and is cheaper and more convenient to administer than methylnaltrexone (Relistor), the other drugs approved for this indication (Table 2), but no direct comparisons are available. It has not been studied in patients taking opioids for cancer pain. Laxatives and stool softeners should generally be tried first. ... "