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" ... The people who donated blood have rare genetic profiles in their human leukocyte antigens (HLA), which makes them broadly compatible with as much as 19 percent of the U.S. population. Other such “HLA-superdonors” have been identified in various biobanks, but the first two donors appear to be the ones compatible with the largest percentages of the U.S. population, based on calculations performed by the company, Palay said. Partly because of the genetics of HLA matching, it is typically more difficult to find superdonors for patients of African descent, he said. That raises social justice questions, in terms of which groups stand to benefit first, Murry said. ... "
" ... The reason for the higher rate of transfusion reactions in pregnant/postpartum women overall isn’t clear. The authors suggested that higher levels of human leukocyte antigen (HLA) antibodies—which increase the risk of an immune reaction—in pregnant women might explain it since these antibody levels are often elevated in pregnant women. However, these antibodies usually increase with additional pregnancies, and the authors did not find any change in reaction risk as the number of women’s previous pregnancies increased. Since this study was retrospective—looking back on past pregnancies and transfusions—researchers may be able to learn more with prospective studies that track women forward in real time. ... "