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" ... But three more decades of drug development and advances in radiation therapy have bought her even more time. In fact, every single drug she has been given since her 2014 recurrence was not available in 1984: letrozole (Femara), palbociclib (Ibrance), capecitabine (Xeloda), paclitaxel (Taxol) and gemcitabine (Gemzar). Two other biologic treatments have also been essential: filgrastim (Neupogen) is a white blood cell growth factor that allows her bone marrow to recover faster from chemotherapy drugs and denosumab (Xgeva) prevents fractures due to an imbalance in bone signaling in response to the cancer cells. ... "
" ... The main finding was that for women who took the combination of letrozole and palbociclib, median progression-free survival was 20.2 months. For those who were randomized to take only the aromatase inhibitor, progression-free survival was 10.2 months. This difference is highly significant from a statistical standpoint (one-sided p-value 0.0004) and from a clinical standpoint. There has not yet been a benefit shown in overall survival. ... "
" ... The main toxicity from letrozole (brand name: Femara) is bone disease. Significantly more women on letrozole for additional years, compared to placebo, experienced bone pain, new-onset osteoporosis and major bone fractures. ... "