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" ... At the outset, I said that Keith has been aggressively pursuing both clinical trials and compassionate use requests for three respective PD-1-targeted antibody therapeutics that are in Phase II or Phase III trials: nivolumab from Bristol-Myers Squibb, MPDL3280A from Roche/Genentech, and lambrolizumab from Merck. GlaxoSmithKline also has another PD-1 antibody in development that they licensed from AmplImmune, AMP-224, currently in a Phase 1 trials that's listed as active, but not recruiting, in the study's ClinicalTrials.gov entry. ... "
" ... MK-3475 (or lambrolizumab) is Merck’s investigational PD-1 specific monoclonal antibody for the treatment of advanced malignancy.The drug essentially enables a patient's immune system to detect cancerous cells that are otherwise extremely hard to identify. T cells can then target and kill these exposed tumor cells. In June 2013, Merck's shares jumped nearly 5% on the news that 38% of the cancer patients under trial responded positively to this drug. Investors have welcomed the company's decision to investigate the drug's effectiveness in combination with other investigational agents. The drug is currently being studied in 17 clinical trials estimated to enroll over 4,000 patients across more than 30 types of cancer. MK-3475 is a new class of drugs and could well be the future of cancer treatment. Bristol-Myers Squibb has a similar drug in clinical trial under the name nivolumab and is expected to garner $6 billion in peak sales. Currently these drugs are being tested for melanoma (skin cancer), and if their usage expands to other cancer types, it could open a much bigger market for these pharmaceutical companies. Merck has already initiated a study to identify other cancer types where the drug can have a therapeutic effect. The company could revive its oncology division if MK-3475 is successful. ... "