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" ... Jason: Yes. I want to draw a distinction between a compound inhibiting a kinase and a compound's mechanism of action being the inhibition of that kinase. There were many cases where we confirmed that a drug was inhibiting the kinases or the protein that it was designed against. For example, we studied inhibitors of the MELK, and confirmed that the drugs were having a direct effect on MELK. At the same time, the inhibition of MELK kinase was not the drug's mechanism of action. That is, it could inhibit MELK, but cancer cells did not care whether MELK was inhibited or not. This suggested that its actual mechanism of action was something else in the cell. ... "