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" ... Manji is embracing ketamine as lead that will help develop other drugs, the first of which could be available by 2017. Four of the NIH scientists who have worked on ketamine in depression have followed him to J&J. The first of these medicines, esketamine, is an isomer of ketamine; like many drugs, ketamine molecules come in two forms with the exact same molecular formula but different arrangements of atoms. By separating out the more effective one, J&J is lowering the ketamine dose. More importantly, esketamine is given not through an intravenous line directly into the blood, as ketamine is, but as a nose spray. Manji says that he believes doctors and patients will be far more likely to use an intranasal drug than an IV. The dose being used is 1/12th that for anesthesia. ... "