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" ... 11. Spritzing oxytocin directly up the nose doesn’t deliver enough of a dose to get molecules past the innate brain-protecting filter known as the blood-brain barrier. In a 2016 paper in the journal Biological Psychiatry, researchers in Scotland demonstrated that “very little of the huge amounts [of oxytocin] applied intranasally appears to reach the cerebrospinal fluid.” ... "
" ... In mice models, the results were even more promising. A single dose, delivered intranasally six hours prior to infection, helped prevent early weight loss and enable their full recovery. Rather than an oral or intravenous point of entry, the researchers focused on the respiratory tract because it is typically the first site of infection and, once the immune system is activated, the first line of defense. In subsequent dose-response experiments, even the lowest dose of diABZI resulted in about 1000-fold inhibition. The potency of the immune reaction triggered by diABZI, the researchers also found, was as robust against the B.1.351 (South Africa) strain as the original (Wuhan) strain. This suggests the treatment might be effective at deterring respiratory viruses more broadly. ... "