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" ... Another case where FDA has observed increases in acetaminophen-associated liver injury is when people take two or more acetaminophen-containing drugs or have taken acetaminophen with alcoholic beverages. This concern was also addressed in my infomail from CVS. If you're taking extra-strength Tylenol (2 X 500 mg) plus Dayquil in the morning, two more extra-strength Tylenol and Nyquil at bedtime, you'd be getting about 3,300 mg of acetaminophen. That's halfway to putting a good deal of hurt on your liver. ... "