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" ... The source infix tells you the original DNA source (and resulting protein sequence) of the antibody. In necitumumab, the "u" immediate preceding "mab" refers to an antibody that is fully of human origin. For comparison, "zu" is for a antibody like trastuzumab (Herceptin) that derives from human and mouse sequences, where the mouse sequences have been converted to encode the human protein sequences. Cetuximab (Erbitux) contains "xi" to denote that it remains in its chimeric form -- this is the reason that necitumumab is expected to cause fewer allergic reactions that cetuximab. ... "