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" ... We’ve known practically since the pandemic’s outset that the pathogenesis of SARS-CoV-2 is highly variable. In most of the people the virus infects it manifests as symptoms that are totally inapparent, but it can also cause death, chronic illness, and everything in between. Not only do the immune responses of humans vary widely in their ability to fend off the virus due to preexisting characteristics and conditions—among them age, medical history, genetics, and current or recent medical treatments—but the virus itself also has potent tools at its disposal for interfering with various immune functions and robbing them of their power. ... "