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" ... In a COVID-19 vaccine, the immunogen might be an artificial protein that mimics the SARS-CoV-2 spike. And if its 'native' structure were ruined by not having the right arrangement of glycans, the immunogen might not elicit an appropriate response to neutralize the coronavirus itself, says Crispin. "Understanding the glycosylation of the native-like protein is really important because it helps you benchmark all the vaccine candidates coming along." ... "