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" ... He points to other examples of efficacy, including imatinib (Gleevec) in chronic myelogenous leukemia (CML), which “has meant that people with CML have a normal life expectancy.” ... "
" ... The drug imatinib mesylate used to treat chronic myelogenous leukemia, or CML is available as a ... [+] branded product and specialty generic. (AP Photo/Carrie Antlfinger) ... "
" ... What a difference ten years makes. A decade ago, the therapeutic landscape for cancer was stark, and there was a sense of palpable frustration; while the 2001 advent of imatinib (Gleevec), targeting a specific molecular defect, suggested a wave of effective precise therapies targeting distinct cancer lesions was about to wash over the field, by 2008 much of this heady optimism had been replaced by a sense of disappointment and disillusionment. There didn’t seem to be very many other Gleevecs around, and cancer yet again seemed to elude domestication. At Merck, where I worked at the time, the oncology group had attracted a number of remarkably talented physicians and scientists, but didn’t have much either on the market or in the pipeline; colleagues at most other companies weren’t faring better. ... "