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" ... But the most frequent adverse reactions were rash (no indication of severity grade) and hypomagnesemia, or low blood magnesium concentrations. Other anti-EGFR antibodies such as cetuximab (Erbitux) also causes depletion of magnesium. The magnesium side effect intrigues me because it's not only a side effect of the anti-EGFR, but it's also observed with cisplatin alone. So I'm curious whether the hypomagnesemia is more serious in the study arm that includes cisplatin and necitumumab. ... "