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" ... They found that over time, the sleep-deprived mice developed progressively larger arterial lesions compared to the other mice. “Specifically, the sleep-disrupted mice developed arterial plaques, or fatty deposits, that were up to one-third larger than the mice with normal sleep patterns,” the NHLBI reported. “The sleep-disrupted mice also produced twice the level of certain inflammatory cells in their circulatory system than the control mice — and also lower amounts of a hypocretin, a hormone made by the brain that is thought to play a key role in regulating sleep and wake states.” ... "