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" ... With the pandemic still very much a part of our everyday lives, the repercussions of continued isolation, stress and lack of treatment options concerns those at NIAAA. But, Dr. Koob notes that we have seen significant progress in the last 50 years in our understanding of the causes and consequences of alcohol use. And, with greater knowledge about the mental, emotional and physical implications of alcohol use and misuse much can be accomplished in prevention, treatment and care. He also notes that new definitions are important. Like hyperkatifeia, as the intersections of neuroscience and alcohol are better identified, we can make more informed decisions knowing why we make the alcohol choices we do, and alter the behaviors that negatively impact our health, safety and wellbeing. ... "