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" ... I am very attuned to looking for underlying risks of antibiotics and try to match the antibiotic’s risk with the patients’ underlying health problems. In fact, I spend inordinate amounts of time trying to teach young staff and hospitalists that quinolones should be avoided in patients with a psychiatric history or on multiple psych meds. My plea usually falls on deaf ears, as it can’t overcome the years of brainwashing from pharma advertising and detailing, and the ease of once-daily administration. Doctors are encouraged to (over-) prescribe once daily medications to reduce administration costs. We are also encouraged to use overly broad-spectrum antibiotics by rigid and punitive practice guidelines. ... "