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" ... Alnylam (NASDAQ: ALNY) is a U.S.-based biopharma company primarily developing RNA interference drugs. The company recently announced that the USFDA has approved its drug Givlaari, which has proven effective in silencing the gene behind the rare metabolic disease acute hepatic porphyrias. This drug was approved 3 months ahead of schedule and only 16 months after the drug was first filed, boosting the outlook for the firm’s revenues and profits. Notably, the company currently only has one commercial drug in the market – Onpattro. Givlaari will soon be the second one. The company’s improved prospects after Givlaari’s approval drove the rally in Alnylam’s stock. ... "
" ... The results so far have been very successful and promising. We are at very early stages, but we have been able to test our method with hepatic cancer and gastric cancer. And currently we’re deploying tests with breast cancer. We will continue doing that with colon cancer and with lung cancer. ... "
" ... To illustrate, the hepatic CYP2D6 enzyme metabolizes 25% of all prescribed drugs, including the pain medicine codeine. The CYP2D6 enzyme converts codeine in to its active metabolite, morphine, which provides its analgesic effect. However, pain relief may be inadequate in individuals who are poor metabolizers because they carry two inactive copies of CYP2D6. Another example is the antiplatelet cardiovascular medicine clopidogrel. Some patients do not respond well to this drug. The variation in treatment response is linked to genetics. Clopidogrel is converted to an active drug through an enzyme named CYP2C19. Individuals with an impaired CYP2C19 metabolism have a lower capacity to convert clopidogrel to its active form. ... "