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" ... Dr. Alexander Fleming: I coined the word “Metabesity”, around 2013, to name the constellation of age-related chronic diseases, from diabetes to cardiovascular and neurodegenerative diseases to cancer to the aging process itself, all with shared metabolic roots, which therefore may be targeted together with common solutions. The intent of naming this target was to encourage concerted effort to invest in and achieve solutions to prevent multiple diseases—and not wait to manage them. Metabesity is sometimes confused with metabolic syndrome and obesity, which are drivers of Metabesity but far from being the only drivers. The emerging geroscience convinced me that after the great successes of medicine against acute diseases and conditions the next frontier could be the prevention of chronic age-related diseases and disabilities. This is a passion on which I want to focus the remainder of my professional life. Around 2016, my co-chair, Larry Steinman, co-discoverer of the MS drug Tysabri and multiple other therapies and long-time former head of the Stanford’s immunology program, and I organized a conference on this motivating theme. Our inaugural conference was in London in October, 2017, set across the street from Wembley Stadium in London. Alex, you were there, and made quite a mark, along with other leaders from various disciplines. We held the next conference at the Carnegie Institution for Science in Washington, DC in October 2019, and here we are now, as a virtual conference in October 2020 due to the pandemic. This has been a pro bono labor of love, and the losses have been covered by our strategic regulatory and clinical development advisory firm, Kinexum. This year, we established the not-for-profit Kitalys Institute to take over organization of future Metabesity conferences and support other initiatives aimed at supporting healthy longevity. ... "
" ... I am encouraged by the fact that there are two major developments, perpetuated by the racing speed of longevity medicine and geroscience. Number one: doctors are shifting from putting a patient on meds to putting a patient on a personalized longevity protocol that becomes a natural, integral, rewarding part of their lives. Number two: society is realizing that it is not important how old one is, but how one shows his/her own age. Remembering this allows one to make sure he or she does not become a slave of the myths about the elderly, but also to be mindful that even at an early chronological age, one might actually experience silent accelerating aging due to modifiable risk factors or pathomechanisms. ... "