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" ... But the scientists could only look at a small subset of neurons in just six patients with bipolar disorder, all of them white males, which limits the generalizability of these findings. "It's hard to extrapolate findings from small samples," said Mansur. "We don't know, for example, if this applies to women, which make up half of the population affected by bipolar disorder." ... "
" ... But what about that Silber study? What's interesting is that very same study was referenced in the Cochrane review cited by Dr. Abenstein. This study did show slightly higher mortality for unsupervised CRNAs compared to supervised CRNAs, but a) it was conducted in a single state (PA), hence limited in its generalizability; and b) had high risks of both selection bias and performance bias; c) the authors concluded the following about these mortality results: "We assessed that co-morbidity had a high risk of imprecision and the remaining increased effect seen may have been due to residual confounding." ... "
" ... “I have concluded that S&O’s content analysis does not support the study’s conclusion because of a variety of fundamental errors in their analysis,” Neuendorf wrote. “S&O’s content analysis lacks reliability, validity, objectivity, generalizability and replicability. ... "
" ... “If you really want to answer this in terms of generalizability, you have to do a randomized trial that targets the older population,” says Chamoun. ... "