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" ... Most of the mutations of note in the London and Boston patients occurred in the spike protein’s receptor binding domain, the target for many drugs and vaccines, as well as the furin cleavage site. Almost all were also point mutations, changes that affected only one amino acid at a time, with the exception of a few deletions. This wasn’t so for the Pittsburgh patient, who had far more deletions in their viral genomes than any other kind of mutation. Additionally, the vast majority were clustered in the N-terminal domain: Δ69-70, Δ141-144, Δ144-145, Δ146, Δ210, and Δ243-244 (Figures 2, 3, 4). If there were mutations in other regions of the virus, they weren’t explicitly stated in the study. ... "
" ... The N679S mutation is located in a critical area for determining the infectivity of the virus particle. For SARS-CoV-2 to affect the cell, two cleavage events are required. One at the furin cleavage site and the other just before the fusion peptide. These cleavage events are the final steps of activation prior to the merger of the virus and the cell. ... "