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" ... Synthetic Biologics (SYN) has developed two products, SYN-004, to help prevent CDI by protecting the gut microbiome from the effects of certain commonly used IV antibiotics to prevent CDI infection and antibiotic-associated diarrhea, and SYN-010, for treating irritable bowel syndrome (IBIS-C) by reducing methane production in the microbiome. The current standard of care for severe CDI, says SYN CEO Riley, doesn’t do anything to prevent the underlying cause of CDI, and involves administering very strong antibiotics, such as vancomycin and fidaxomicin. While they may ultimately eradicate the CDI bug from CDI patients, "these antibiotics may inadvertently have a long-lasting and detrimental impact to a patient’s microbiome by eliminating bacterial species which my never return, ultimately leading to additional unintended complications, Riley says." ... "