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" ... Before this latest research, some of the investigators had previously shown that neurons derived from stem cells of people with bipolar disorder were hyper-excitable, and lithium reduced that excitability. In other words, with lithium treatment, neurons didn't fire or signal to each other as easily as they did before, without lithium treatment. The research group, from the Salk Institute in La Jolla, found that this occurred only in cells of bipolar disorder patients who were responsive to lithium treatment. ... "
" ... If we have a reputation for excitability and volatility among peers, they will likely practice avoidance. Of course, peers are typically our rivals for upward mobility, so the more politically savvy ones will spread the word about our volatility or even look for ways to trigger it in front of our boss. ... "
" ... The Dkk1 and control mice were compared after the four-week, on-off Dkk1 period. The ability of sending neurons to excite receiving neurons was not significantly different between the two groups of mice. In other words, synaptic excitability was completely restored in the Dkk1 mice. The Dkk1 mice also exhibited full restoration of neural plasticity. ... "