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" ... Henderson's findings about hormone therapy and the brain, as well as the recent findings about the heart, come out of the "Early vs. Late Intervention Trial with Estradiol," or ELITE. Designed to answer the question of whether the timing of hormone therapy makes a difference on any tissue, ELITE enrolled two groups of healthy women. One group was fewer than six years past menopause, while the other was a decade or more past menopause. They were randomly assigned to take pills containing estradiol, a different type of estrogen than the one used in the WHI, or placebo pills. ... "