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" ... It would be wise to view this trial with some caution. In his editorial Hacke writes that "it is premature to conclude that there is no longer equipoise regarding thrombectomy. We need and will get results from other well-designed trials." Don't expect similar caution from other corners, though. The pressure from industry and KOLs (key opinion leaders) supported by industry will be quite intense. Indeed, even before the trial was published in the New England Journal of Medicine PR companies were offering up embargoed interview opportunities to journalists with trial investigators and other leading figures in the field. Writing in Mass Device, Brad Perriello notes that "medical device makers are jumping on the bandwagon of the Mr. Clean trial" and "wasted no time in touting the results." Device makers whose thrombectomy devices were used in the trial include Penumbra, Covidien, and Stryker. ... "
" ... We need to carefully examine the “big picture” before simply jumping back to what we had, and often complained about, before. Rather than simply making assumptions about what the best next steps are, each employer and employee should look to deliberately evaluate and understand the pros, cons, and points of equipoise of their specific business environments, and then develop a dynamic approach to shape new best practices. ... "