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" ... The combination therapy is comprised of three drugs (elexacaftor, ivacaftor and tezacaftor), which work together to help improve function in the CFTR protein. In most cystic fibrosis patients this protein is defective and does not function as well as it is meant to. As a result, patients experience an increase of mucus in their lungs. This mucus is abnormally thick and sticky, and can lead to breathing obstruction, infection and even death. ... "