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" ... DNA consists of two complementary strands that forms the famous double helix, while RNA is a mostly single-stranded molecule. Roughly speaking then, DNA is twice as thick as RNA, which makes it much harder to squeeze DNA through the small pores in a cell's membrane. As a consequence, vaccination with DNA requires a special tool that applies an electric field to widen pores (an electroporator), which is obviously less practical than using common equipment like a syringe. So yes, RNA is better than DNA — at least when administering a vaccine. ... "