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" ... For decades, the vast majority of drug discovery programs have taken a very reductionist approach by narrowly assuming there are single targets that influence disease biology; one simple biological button that we hit to influence cell behavior and treat a disease. This approach has yielded some notable success in the past. But it’s clear that we have exhausted the “low-hanging fruit” of easily druggable single targets. Furthermore, target-based hypotheses have led to many recent failures among potential new medicines. ... "