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" ... Creative flow is the experience of being completely immersed, present, focused and in the zone. The inner critic and mental chatter are quieted, novel ideas are born and random associations collide. Mental effort and control are relinquished to procedural memory, a type of memory that allows skill and expertise to take over. “Novelty generation involves a downregulation of the frontal control networks,” says Rex Jung, neuropsychologist and brain imaging researcher who studies creativity and intelligence. “It’s a back and forth between the medial prefrontal cortex and the cognitive control network which involves the dorsolateral prefrontal cortex.” Turning down the volume on the cognitive control network helps mute the voice of the inner critic. It sets in motion the maneuverings of powerful, less self-conscious regions of the brain, adept at skill execution. These networks are important for creativity with a capital C. Capital C creativity is a term neuroscientists use to describe states that give rise to the world’s great innovations and works of art. ... "
" ... Further analysis showed that men with haplogroup I showed downregulation of adaptive immunity as well as upregulation of inflammatory response pathways in their macrophages (immune system cells) compared with carriers of other Y chromosome types. These data show that predisposition to CAD in men might, at least in part, be determined by the paternal lineage of their Y chromosome and that this effect on risk of coronary artery disease is most likely mediated through the immune response. ... "