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" ... The solution to this problem was found in high-throughput screening (HTS)–a technology discovery by John Williams and Dennis Pereira at Pfizer. HTS is the type of “industrialization” that Scannell rails against. It is an empirical approach based on testing millions of different compounds in microarray format to try to find a “lead” – a compound with some small degree of activity that the team can use as a starting point. Much like cytosine was a starting point for the Chantix discovery team, any team running an HTS hopes to get a similar “lead” to enable the start of the discovery testing process. ... "