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" ... Before flu or cancer, Moderna’s next, non-Covid-19 vaccine to reach the public will likely be its vaccine for cytomegalovirus, or CMV. A harmless virus for most healthy adults, CMV can be passed from parent to baby in the womb. It is the number one cause of birth defects in the U.S., where 1 in 200 babies are born with the virus. In infants, the virus can cause hearing loss, vision loss, learning disabilities and other developmental disabilities. Bancel says that scientists have tried to create a vaccine to prevent CMV for more than 20 years, and Moderna’s current vaccine is a “very complex” shot that involves six different mRNA strands per vial. Despite those challenges Bancel says that so far, “the phase 1 and phase 2 data look very strong.” ... "
" ... Cidofovir had been sold by Gilead Biosciences as an intravenously administered antiviral drug as Vistide® and was approved to treat cytomegalovirus infections of the eye, called CMV retinitis. The majority of the population is already infected with CMV but it only becomes a problem when the immune system is suppressed, such as in HIV/AIDS or with the immunosuppression regimen used for a hematopoietic bone marrow transplant. But cidofovir has activity against all five families of double-stranded DNA virus that cause human disease and death – including smallpox variola virus, herpesviruses, polyomaviruses, and adenovirus, the one currently afflicting young Joshua Hardy. ... "
" ... The two major challenges of immunotherapy are identifying what to target in each different type of cancer cell and then getting the immune system to cooperate when the cancer has so severely weakened it. This small trial tried something new to overcome both those challenges. First, instead of targeting a mutation in the brain tumor cells, they targeted exactly the sort of beast the human immune system was naturally designed to fight: a virus. Nearly all people have been exposed to cytomegalovirus, a relatively benign member of the herpesvirus family that rarely causes illness but remains dormant in the bodies of those exposed to it. It turns out that cytomegalovirus reactivates in glioblastoma cells, probably because of the immunosuppressive power of the tumor cells. ... "
" ... Viral infections from cytomegalovirus (CMV), Epstein-Barr (EBV), HIV and Zika have also been associated with subsequent Guillain-Barré. ... "