Caution! The site can't guarantee, that text has age permission. The site is not recommended, if you are less than 18 years old.
The site shows example sentences for English words. How the word or phrase could be used in a sentence?
" ... "It appears that the restriction of use in patients with creatinine clearance <95 ml/min applies only for NVAF indication. The creatinine clearance cut off used for impaired renal function during the FDA panel meeting was <80 ml/min; based on this criterion, nearly one-third had normal renal function representing a large subgroup in whom treatment with edoxaban would yield unfavorable results compared with warfarin. The final FDA approval appears to have relaxed this criterion to CrCl <95 ml/min, thereby expanding the pool of patients eligible for edoxaban. Regardless, there is no unique advantage this drug offers relative to existing therapies. As such, clinical acceptability and marketability will pose a major challenge for this drug." ... "
" ... Besides the small sample size—one might need tens or even hundreds of subjects for the study to have much validity—the research was dogged by other problems. The results are an outlier when compared to other exposure studies. The use of spot urine samples with such small group sizes is not a rigorous approach. Additionally, as the authors note, they didn’t present the corrected values for creatinine, which otherwise allows researchers to correct for urine concentration—how dilute is it depending on how much water one drinks. That throws the entire study in doubt. They also didn’t analyze the diet in a rigorous way. The phthalates could be a biomarker of dietary fat consumption, which means they could have been eating a higher than typical amount of dietary fat or significantly more food. ... "
" ... But gene therapy experts pointed to other data points as more interesting than the ones that Wall Street has fixated on. For instance, boys (for genetic reasons, they’re all boys) with Duchenne have high levels of creatinine kinase, an enzyme involved in the destruction of muscle. In the study, the three boys who have been followed for at least two months saw levels of creatinine kinase drop 87% from about 30,000 units per liter. ... "
" ... Irena Bucci was receiving follow-up care after delivering her second baby when the obstetrician discovered a problem with her kidneys. “My creatinine was rising,” creatinine being a waste product normally cleared out of the bloodstream by healthy kidneys, “and my doctor didn’t know why. I didn’t have high blood pressure or diabetes,” two diseases that are common causes of kidney failure. Bucci met with a number of kidney specialists, in hopes of uncovering the cause of her kidney failure. “But the tests didn’t discover one. And without a diagnosis, they couldn’t figure out how to treat my illness. They told me it was just a matter of time before my kidneys failed.” ... "