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" ... Taken together, PWS and craniopharyngioma offer two high impact opportunities: very defined patient segments with no current effective standard of care, both are homogenous disease states related to obesity, where we are confident the underlying pathways are at work, with a clear risk-benefit favoring active intervention and pharmacotherapy. By approaching the introduction of beloranib via a measured approach, tackling very defined obesity-related populations, we can ensure only those patients deemed appropriate for the drug are receiving it (preventing abuse through inappropriate usage by “healthy” overweight or mildly obese population). ... "