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" ... As a side note, “cowpox” and “horsepox” may technically be misnomers. Although people first discovered the viruses in cows and horses, respectively, Duggan, Klunk, and their colleagues point out that “neither cows nor horses are considered the natural reservoirs of these viruses.” What are their natural reservoirs? Virologists and ecologists are still working on that question. ... "
" ... Jenner’s solution was to instead inoculate people with cowpox. This also encouraged the production of antibodies against smallpox, but was far less likely to make people ill, as the disease affected cows - not humans. ... "
" ... Vaccine skeptics of the time pointed out that those communities which had aggressively vaccinated people also made other public health changes that might explain the relative health of their populations. For example, before the smallpox vaccine came into widespread use, many public health experts pushed for people to be inoculated with the actual smallpox virus. The vaccine, you might remember, is derived from cowpox. Inoculations, on the other hand, were derived from the actual smallpox virus. With inoculation, doctors purposely infected people with very tiny amounts of the smallpox virus, hoping that recipients would experience a mild form of the disease and thereby be protected from a more severe illness. Inoculation was much riskier than vaccination. Some people got terribly ill after their inoculations. Others managed well enough but still unwittingly spread the disease to others, who didn’t fare so well. ... "