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" ... As the skin is the primary interface between our body and the external environment, its most critical role is to provide a strong physiological barrier, which is mediated by the outermost layer of the epidermis, the stratum corneum. As we heard from Dr Giuseppe Valacchi at our inaugural Science of Aging symposium in 2019, exposure of skin to air pollutants alters the functions of epidermal proteins and damages lipids and DNA, leading to a range of skin disorders. Individuals with altered barrier function are particularly sensitive to pollution-induced skin disorders. ... "