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" ... "What we need now, as I suggested in my editorial, is a randomized control trial that might use placebo or might use an active comparator of some kind, perhaps another antidepressant, that would allow us to see what is the specific impact of psilocybin" Reynolds said. ... "
" ... Let’s be in no doubt: this brave new world is very much to the advantage of patients and payers. Better comparator data will, in itself, lead to better outcomes and saved dollars. ... "
" ... Porsche has enviable engineering depth allied with sharp marketing, and though only Mercedes-AMG and BMW M can offer a CUV with roughly comparable performance, soon that will not be the case. Jaguar’s big-horsepower V8 F-Pace, based on long-proven elements, is an obvious comparator, though its hefty supercharged V8 will deliver a dramatically different character. Alfa Romeo’s Stelvio Quadrifoglio has a peaky 505 horsepower and virtually identical torque in a narrower rev band, a car more clearly compromised for track performance, whereas Macan Turbo Performance Package is very much a daily driver that can match the Alfa’s performance in on-road conditions. The Alfa Romeo remains as-yet unproven in build and materials quality as well as actual performance. ... "
" ... Presumably the foreign drug prices used as a reference or benchmark would include the comparator countries named in the HHS report: Austria, Belgium, Canada, the Czech Republic, Finland, France, Germany, Greece, Ireland, Italy, Japan, Portugal, Slovakia, Spain, Sweden and the United Kingdom. Four of the sixteen comparators - the Czech Republic, Greece, Portugal, and Slovakia - stand out as nations with much lower Gross Domestic Product (GDP) per capita than the U.S.; about one-third of the U.S. Given that relative price levels are a function of income or GDP per capita, basing U.S. drug prices on a basket that includes comparators with significantly lower incomes is inappropriate. ... "
" ... “McDaniel did not present evidence of a comparator who similarly violated Progress Rail’s cell phone policy or lifting policy—or any safety rule, for that matter—and also complained about overtime, but received better treatment,” the panel stated. ... "