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" ... Of the 64 possible combinations of codons in every three-nucleotide sequence, there are six possible codons that encode arginine. CGG is rarely found in coronaviruses, and back-to-back CGG-CGG codons have never been seen in other betacoronaviruses. The assertion is that the very existence of this furin-cleavage site is suggestive of a lab origin for the virus, and that the back-to-back CGG-CGG codons are the smoking gun. ... "
" ... There’s no technological reason why a researcher couldn’t have switched the codons for one amino acid, like tyrosine, into the codons for another one, like alanine. But then what? You can't make a virus more deadly — or, at the very least, you have no way of knowing what that switch would do to the virus — by switching out one amino acid for another. No virologist living today has that knowledge; that's not how this scientific field works. Without intensive and extensive studies of the virus in human beings, which we know we need because of the inherent genetic variabilities in human populations, we cannot predict what the resultant effects in humans will be. ... "