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" ... In summary, these results suggest that it would be valuable to add to the current cocktails that recognize the receptor-binding domain. One or two additional antibodies that recognize highly conserved epitopes, perhaps in the vicinity of the fusion peptide, may be most useful, as this region was conserved across many variants and viruses. Additionally, we have commented that highly effective cocktails for treatment and prevention might be combined with combination chemoprophylaxis with alternate drugs for maximum effect, creating multiple targets on the spike protein for neutralization (Figure 4). It is unlikely that variants can quickly arise that are resistant to antibody and drug cocktails simultaneously. As new variants spread through populations, this combination strategy may be successful in the prevention of new variant-associated outbreaks. ... "