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" ... The funding will support Prokarium’s work addressing cancer therapeutics through microbial immunotherapy. Their oncology platform, Onconella, uses proprietary microbial strains to find and colonize solid tumors. The therapy also triggers a patient’s innate immune response to destroy the cancerous cells. Fjallman says that the proprietary strains are also being engineered to deliver various cargo molecules to the tumor site, including chemokines and cytokines. These cargo molecules can ultimately modulate the tumor microenvironment (TME)—the complexes and structures surrounding the tumor, including blood vessels, immune cells, fibroblasts, and signaling molecules. The ability to modify this environment is extremely important. The TME is closely related to the tumor and can significantly affect its growth. “We see this triggering to innate immunity and the modulation of the TME as key competitive advantages and key to success in humans,” says Fjallman. ... "
" ... The levels of 18 chemokines were measured in all three groups. The levels of many (including TNF TRAIL, Mi-CSF, Gro-D. GCSF, and Il-6) were significantly increased in patients who had been infected versus the uninfected matched controls. There was no detectable difference in the level of chemokines those with asymptomatic infections and uninfected controls. This observation strongly implicates chemokines as a causative agent of observed Covid-19 symptoms. Recall that SARS-CoV-2 damaged the lungs of the majority of those who were asymptomatic. ... "