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" ... Unfortunately, there are times when post-marketing studies can indeed take years to carry out. A prominent case involved the arthritis pain reliever, Celebrex (generic name: celecoxib). Celebrex is a COX-2 inhibitor which was designed to maintain the powerful non-steroidal anti-inflammatory properties of traditional NSAIDs while being far better tolerated particularly with respect to gastrointestinal toxicity. Celebrex (Pfizer) and another COX-2 inhibitor, Vioxx (Merck), initially were extremely successful and were among the biggest drug launches of all time. However, after it had been on the market for four years, Merck pulled Vioxx off pharmacy shelves because the drug elevated the risk of heart attacks and strokes in arthritis patients. ... "