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" ... Scientists don't know for sure how this happens, but they think it has a lot to do with the biology of stress. "The hypothesis for Takotsubo syndrome has always been that the primary mechanism is: a stress response occurs, it leads to production of catecholamines, the neurohormones of stress, and those stress hormones can cause injury to the heart cells and ischemia, or decreased blood supply, by affecting blood vessels around the heart," said Ilan Wittstein, assistant professor of medicine at Johns Hopkins University. "So anything that can cause a big stress response could potentially cause Takotsubo." ... "