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" ... PDE5 inhibitors are also problematic in individuals with underlying heart disease and cardiac defects. It's unknown whether the 35-year-old ballplayer and former husband of Khloe Kardashian had such a medical history. However, Odom is known to have had dependence issues with alcohol and other drugs, dating back to 2001. Excessive drinking, acutely or in the long term, can cause heart muscle problems called cardiomyopathies. ... "