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" ... Chile peppers get their "heat" from an evolutionary collaboration between their biochemistry and yours: they produce one or more capsaicinoids, which are chemical irritants, and you produce the capsaicin receptor to which those biochemicals bind. This binding is translated by your brain as being hot and painful, which then causes your body to respond by sweating and choking, with numbness of the face and hands, perhaps even some skin blistering, and then ... there's that delightful endorphin high. ... "