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" ... Though GS-6027 and cabotegravir are very different drugs, they do have one important thing in common in addition to their long-lasting effect: they have an enormous therapeutic index. A therapeutic index is essentially the ratio between how much a drug harms the patient and how much it harms the virus, tumor, or other agent that is causing the illness. Ideally, you want drugs that do a great deal of damage to the agent but leave the rest of the patient free from harm. These two drugs do just that, as they target functions that are specific to the virus and have no corresponding function in human biology. ... "