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" ... “I do believe that the power of randomization, the power of blindedness, it’s what enables us to control for all the things we don’t know about complexity of human life and human biology. To think we’re going to take that away, and then be able to really determine the efficacy of a medicine, puts a lot on the statistics that I don’t think we have. I’m more of a real world evidence realist, after we have randomized placebo controlled data that really tells us that something has the effect we think it does, then to explore more effects or explore more uses through real world evidence makes a lot sense, but I don’t see this as a panacea that suddenly will make the world much easier." ... "